You are watching: Can you take ibuprofen and benadryl

 I take ibuprofen p.m. on occasion — maybe once a month or so — to help me get to sleep. It seems to work. Is that okay?

A. Ibuprofen p.m. is a combination medication that contains ibuprofen and diphenhydramine, which is the active ingredient in Benadryl, an antihistamine taken for allergies.

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