On the main menu, tbelow are a list of difficulties you can effort. Clicking one starts the game, presumably with distinctions depending on the challenge.

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What is the locked difficulty, and what is various about each challenge?


Let"s answer via a small aid from the wiki. Each difficulty is played as Isaac and also each one has a particular goal.

Dark was the Night: Gives you Curse of Darkness (you cannot see the minimap). Ends after killing Mom. Completing this obstacle unlocks The Candle, a usable item through instant recharge that throws flames that damage anything on their course.

7 Years Bad Luck: Gives you Curse of the Lost (still unclear what this curse does). Ends after killing Mom. Completing this obstacle unlocks the Lucky Toe, a trinket that gives you a possibility of additional items as soon as opening chests or "X" rocks.

Large Marge: Gives you Curse of the Labyrinth (extra big double levels). Ends at the initially Depths boss. Unlocks the Burnt Penny, a trinket that grants a opportunity of dropping a bomb as soon as you collect a penny

9 Deaths: Gives you the Dead Cat item (9 1-heart stays available). Ends after killing Mom. Unlocks Guppy"s Tail, a things that, if combined via Guppy"s Head and Guppy"s Paw, transforms your appearance into a flying cat (various other impacts still unknown)

Lord of the Flies: Clintends to give you Unidentified, yet actually provides you Infestation and also The Mulligan (the first produces attack flies from your body once hit, the second once hitting enemies). Ends at the Womb"s first boss. Unlocks the Fish head, a trinket that has actually a comparable result to The Mulligan.

The Doctor"s Revenge!: Gives you the Dr Fetus item and also the Doctor"s remote. Still unclear if it clears treasure rooms. Ends after killing Mom"s heart. Completing the obstacle unlocks the Mega Fetus a missile shooting Dr Fetus.

Meat 4 Evar!: Starts you out via lv. 4 Meat Boy. Ends after killing Mom"s heart. Completing this obstacle unlocks the Super Fan, a saw-looking item that increases all stats by 1, exact same as the Halo.

Spider Boy!: Gives you the Spider"s Bite item, and the Mutant Spider. Ends after killing Mom"s heart. Completing this difficulty unlocks the Spider Butt, a usable item through a 2 room recharge that damperiods all enemies in the room and slows them.

Isaac Was Good Today: Gives you the Divine Grail and the Halo. Ends after killing Satan. Unlocks Counterfeit Penny, a trinket that has a chance to generate a secondary cent as soon as collecting money.

The Purist: You begin with no items, spacebar or passive. Treacertain rooms are removed from the maps as well. Bosses and also special events still deserve to drop collectables. Ends after killing Isaac. Unlocks the Egg Sack, a long leg that follows you and stomps opponents.Unlocked by beating Isaac.

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There are still things to uncover, I"ll store the answer updated as shortly as I find them.